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Assistant/Associate Professor, University of Illinois at Chicago
RNAi in gene regulation and small RNAs as biopharmaceutical agents
The Center for Pharmaceutical Biotechnology and the Department of
Biopharmaceutical Sciences, University of Illinois at Chicago, invite
applications for a tenure-track faculty position at the level of
Assistant or Associate Professor in a general area of RNAi-based gene
regulation and/or small RNAs as biopharmaceutical agents.
Responsibilities include developing a strong, externally-funded research
program and teaching in graduate and professional programs. The
successful candidate will have joint appointments in the Center for
Pharmaceutical Biotechnology and the Department of Biopharmaceutical
Sciences. PhD and at least one year of postdoctoral experience in areas
related to biology of RNAi and/or small RNAs are required. Candidates at
the Assistant Professor level must have strong potential for attracting
extramural funding; candidates at the Associate Professor level must
have a strong record of successful extramural funding. Position
available Spring, 2008. For fullest consideration, send curriculum
vitae, description of research interests and three letters of reference
by November 1, 2007, to cpbhr{at}uic.edu or
Dr. Alexander Mankin, RNA Search Committee
Center for Pharmaceutical Biotechnology - m/c 870
University of Illinois at Chicago
900 S. Ashland Ave.
3052 MBRB, Chicago, IL 60607-7173
(electronic applications encouraged)
UIC is an AA/EOE
Group Leader-Aptamer Technology (Scientist) #035115,
University of Miami Miller School of Medicine
The University of Miami Miller School of Medicine and the Sylvester
Comprehensive Cancer Center have embarked on a broad initiative to
develop immune-based treatments for cancer, infectious diseases (HIV &
HCV), autoimmunity (diabetes), and improve organ transplantation, which
will be coordinated by the recently established Dodson Interdisciplinary
Immunotherapy Institute. In recognition of the emerging role of RNA
therapeutics, the DIII and SCCC are establishing an initiative to
develop aptamer-based technologies, both as modulators of cellular
activity (agonists or antagonists) as well as targeting agents (for
siRNA). The purpose of the proposed initiative is to capitalize on the
potential of this technology and provide a competitive advantage to the
SCCC and DIII.
This individual reports to the Director of the Dodson Interdisciplinary
Immunotherapy Institute and is responsible for developing new methods
for aptamer selection and design of aptamer-siRNA conjagates. This
individual will provide researchers with training and hands-on expertise
with aptamer selection methods, including constant trouble-shooting
advice and supply of key reagents necessary for the selection process,
such as modified nuclesoides and mutant polymerases.
Minimum qualifications include a Ph.D. or equivalent degree plus ten
(10) years of relevant experience and productivity in molecular biology.
Extensive track record in nucleic acid research, preferably RNAi and/or
aptamers is required. Candidates must have experience in real-time
PT-PCR, cloning and nucleic acid binding assays, mammalian tissue
culture including transfection experiments. An appropriate combination
of relevant education, experience and/or certifications will be
considered.
Discover all this and countless opportunities that reward your talent.
The University of Miami Miller School of Medicine is proud to offer
those who lead with us competitive salaries, medical and dental
benefits, tuition remission, vacation, university paid holidays and much
more.
For more information and to apply online, visit:
www.careers.med.miami.edu.
The University of Miami is an Equal Opportunity/Affirmative Action Employer.
RNA Biochemistry, Molecular Biology and Virology, University of Missouri School of Medicine
Applications are invited for Postdoctoral or Senior Research Scientist
level positions in several areas of basic and applied RNA research:
• An NIH-funded project developing RNA and ssDNA aptamers to treat,
prevent and detect HIV-1 infections. Core areas of interests include
biophysical analysis of aptamer-protein interactions, developing
aptamers for microbicide and gene therapy strategies, and evaluating and
overcoming aptamer-resistant HIV-1.
Contact burkedh{at}missouri.edu
• A NASA-funded project developing ribozymes for use in metabolic
engineering and gene therapy and to advance RNA World theories. Core
areas of interest include identifying new ribozymes for metabolically
relevant biochemical reactions (such as protein and small molecule
phosphorylation), determining how ribozyme structures contribute to
catalytic mechanisms and evolution, and using artificial ribozymes to
modulate intracellular metabolism.
Contact burkedh{at}missouri.edu
• An NIH-funded project characterizing the processing of pre-mRNAs
generated by adeno-associated viruses (AAVs), important DNA virus
vehicles for gene therapy applications. Core areas of interest include
determination of how 5’ exon definition in AAV governs alternative
splicing and competing alternative polyadenylation, and how the AAV Rep
protein acts as a trans-activator of co-transcriptional RNA
processing to influence these events.
Contact pinteld{at}missouri.edu
• An NIH-funded project characterizing how AAV-generated RNA induces and
evades cellular innate immunity. Core areas of interest include
determining how AAV RNA activates cellular PKR, how translation of AAV
mRNAs is specifically inhibited following the subsequent phosphorylation
of eIF2-a and how these RNAs escape such inhibition following expression
of PKR antagonists.
Contact pinteld{at}missouri.edu
Successful candidates will bring insight and expertise in appropriate
areas that will allow rapid advances of these multidisciplinary
programs. S/he will also be creative, enthusiastic, effective, and bold,
and will have demonstrated a capacity to learn new things and to work
well with others. Candidates should possess a Ph.D. or equivalent
degree. Salary is highly competitive, in addition to the affordable,
quality living environment of central Missouri.
To apply, please send CV, a statement of how you anticipate contributing
to the indicated research enterprise, and the names and contact
information of 3 references to Prof. Donald H. Burke or Prof. David
Pintel at the email address listed above. Informal inquiries are also
welcome.
University of Missouri School of Medicine
Department of Molecular Microbiology & Immunology
Life Sciences Center, 1201 E. Rollins St.
Columbia, MO 65211-7310 USA
To request ADA accommodations contact (573) 884-7278 (V/TTY).
The University of Missouri is an AA/EOE. Women and minorities are encouraged to apply.
Postdoctoral Fellow Position, University of Washington at Seattle
I am looking for a highly motivated Postdoctoral Fellow to study RNA
localization in a giant unicell, Acetabularia acetabulum. We have
identified 3 conserved domains in our EST libraries whose functions we
would like to understand. In specific, we would like to test if they act
like "zipcodes" to tell mRNAs where to go in the organism, or as
stability signals, etc. Microinjection studies will determine 1) what
happens when these conserved elements are altered in order, number etc.;
2) on which portion of the cytoskeleton do fluorescent beads or
fluorescently tagged RNAs travel during development with and without
these consensus regions; 3) whether there are some conserved sequences
that direct an mRNA to the apex or base of the organism; 4) the role of
the nucleus (if any) in directing RNA trafficking. Imaging with confocal
and/or epifluorescence video microscopy and fluorescence in situ
hybridizations will be the main assays.
The successful candidate will perform the microinjections, analyze the
fluorescence microscopy data and will work closely with a technician who
will assist in making the molecular constructs. This work will be
complemented by searches for localized, stable transcripts of A. acetabulum ESTs or genes. The successful candidate will be expected to
apply for independent postdoctoral fellowship(s) during this 2 year NSF
postdoctoral period. Start date for this position is immediate.
Contact:
Dr. Dina F Mandoli
Tel : (206) 543-8917
Email:mandoli{at}u.washington.edu
Postdoctoral Position, Department of Biochemistry and Biophysics at Texas A&M University
An NIH-funded post-doctoral position is immediately available to study
trypanosome RNA editing catalyzed by a mutisubunit complex termed the
łeditosome˛. Ongoing research includes investigation of the
organization of RNA-protein interactions in assembled editosomes.
Independent and enthusiastic candidates with a strong background in
molecular biology and biochemistry are encouraged to apply. The
fellowship ($45,000-50,000) is for three years, or longer depending on
funding. Applicants are encouraged to informally contact the head of
the group, Jorge Cruz-Reyes for more information on the projects. Our
recent publications include: RNA 2006 (In press); NAR 2005 (33:1-10);
RNA 2004 (10:914-920).
Please send a curriculum vitae and the names and addresses of two
references by email or regular mail to:
Dr. Jorge Cruz-Reyes
Assistant Professor
Department of Biochemistry and Biophysics
Texas A&M University
2128 TAMU
College Station, TX 77843-2128
Tel. (979) 458-3374 / Fax. (979) 862-4718
Email:cruzrey{at}tamu.edu
Research Associate (Associate Professor), University of Chicago
The University of Chicago’s Department of Human Genetics is seeking a
qualified applicant for a full time Research Associate position to join
a program investigating the genetic basis and neurobiology of several
human developmental disorders. We are seeking a mature, motivated
candidate with extensive background and skill in molecular genetic
methods including sample preparation, DNA and RNA analysis including
quantitative RT-PCR, DNA cloning, cytogenetics, fluorescence in situ
hybridization and especially comparative genome hybridization. Ph.D. in
biology or a related field required. Expertise in use of genome
database resources is essential. The applicant must be able to design
and conduct experiments independently, prepare and present their work
at national meetings, and write scientific manuscripts and grant
applications.
Interested applicants should send electronic copies of curriculum
vitae, a short summary of research plans and the names of three
references to:
Human Genetics Search Committee at
search{at}genetics.uchicago.edu
Department of Human Genetics
The University of Chicago
920 East 58th Street, CLSC 507
Chicago, IL 60637
http://www.genes.uchicago.edu
The University of Chicago is an Affirmative Action/Equal Opportunity Employer.
Interested in other job opportunities?
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Copyright © 2008 by the RNA Society.
